Wolf Dieter Hardt
The Hardt lab is located at the Institute of Microbiology of ETH Zürich, Switzerland. We study the molecular, cellular and evolutionary concepts of bacterial infections. Salmonella Typhimurium, a common zoonotic pathogen and a frequent cause of food-borne diarrhea, serves as our primary model. The disease results from complex and dynamic interactions between the pathogen's virulence factors and its metabolism with the normal microbiota inhabiting the gut, with the host's gut epithelium and its immune system. We integrate expertise from biochemistry, microbiology, genetics, cell biology, biomedical imaging, systems biology, mathematical modelling, immunology and evolutionary biology to decipher the basic principles explaining the pathogen's biology, the host's mucosal immune response, and the function of the microbiota during discrete stages of the disease.